Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4398390..4399204 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag H1C97_RS21135 Protein ID WP_001054376.1
Coordinates 4398947..4399204 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag H1C97_RS21130 Protein ID WP_001309181.1
Coordinates 4398390..4398935 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS21105 4394081..4395394 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
H1C97_RS21110 4395406..4395684 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
H1C97_RS21115 4395681..4396802 - 1122 WP_000010829.1 M42 family metallopeptidase -
H1C97_RS22700 4397047..4397163 - 117 Protein_4102 VOC family protein -
H1C97_RS21120 4397201..4397419 - 219 Protein_4103 hypothetical protein -
H1C97_RS21125 4397588..4398334 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
H1C97_RS21130 4398390..4398935 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
H1C97_RS21135 4398947..4399204 - 258 WP_001054376.1 hypothetical protein Toxin
H1C97_RS21140 4399581..4399826 - 246 Protein_4107 GNAT family N-acetyltransferase -
H1C97_RS21145 4399942..4401182 + 1241 Protein_4108 DNA helicase -
H1C97_RS21150 4401765..4402745 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
H1C97_RS21155 4402810..4403916 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE / fimA / fimI / fimC 4383445..4410181 26736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T289279 WP_001054376.1 NZ_LR778151:c4399204-4398947 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT289279 WP_001309181.1 NZ_LR778151:c4398935-4398390 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References