Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3436119..3436750 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag H1C97_RS16685 Protein ID WP_001259385.1
Coordinates 3436475..3436750 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag H1C97_RS16680 Protein ID WP_000593555.1
Coordinates 3436119..3436478 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS16650 3431230..3431703 + 474 WP_001161650.1 PTS sugar transporter subunit IIA -
H1C97_RS16655 3431700..3431981 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
H1C97_RS16660 3432058..3433416 + 1359 WP_021565455.1 PTS galactitol transporter subunit IIC -
H1C97_RS16665 3433409..3434918 + 1510 Protein_3246 carbohydrate kinase -
H1C97_RS16670 3434908..3435177 + 270 WP_000933061.1 HPr family phosphocarrier protein -
H1C97_RS16675 3435209..3436069 + 861 WP_001131788.1 class II aldolase -
H1C97_RS16680 3436119..3436478 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1C97_RS16685 3436475..3436750 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
H1C97_RS16690 3436809..3437933 - 1125 WP_021565453.1 ABC transporter permease -
H1C97_RS16695 3437933..3440668 - 2736 WP_021565452.1 ribosome-associated ATPase/putative transporter RbbA -
H1C97_RS16700 3440665..3441732 - 1068 WP_021565451.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3430459..3445572 15113


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T289275 WP_001259385.1 NZ_LR778151:c3436750-3436475 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT289275 WP_000593555.1 NZ_LR778151:c3436478-3436119 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References