Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2850884..2851538 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag H1C97_RS13735 Protein ID WP_000244772.1
Coordinates 2850884..2851291 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag H1C97_RS13740 Protein ID WP_000354046.1
Coordinates 2851272..2851538 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS13715 2846841..2848574 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
H1C97_RS13720 2848580..2849290 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H1C97_RS13725 2849315..2850211 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H1C97_RS13730 2850323..2850844 + 522 WP_001055874.1 flavodoxin FldB -
H1C97_RS13735 2850884..2851291 - 408 WP_000244772.1 protein YgfX Toxin
H1C97_RS13740 2851272..2851538 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
H1C97_RS13745 2851781..2852761 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
H1C97_RS13750 2852838..2853497 - 660 WP_000250274.1 hemolysin III family protein -
H1C97_RS13755 2853661..2853972 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
H1C97_RS13760 2854017..2855450 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
H1C97_RS13765 2855507..2856250 - 744 WP_021564907.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T289273 WP_000244772.1 NZ_LR778151:c2851291-2850884 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT289273 WP_000354046.1 NZ_LR778151:c2851538-2851272 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References