Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2406077..2406702 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1C97_RS11625 Protein ID WP_000911330.1
Coordinates 2406077..2406475 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H1C97_RS11630 Protein ID WP_000450524.1
Coordinates 2406475..2406702 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS11605 2401984..2402184 + 201 WP_000383836.1 YpfN family protein -
H1C97_RS11610 2402265..2402963 - 699 WP_000679812.1 esterase -
H1C97_RS11615 2403037..2405052 - 2016 WP_021565358.1 tRNA cytosine(34) acetyltransferase TmcA -
H1C97_RS11620 2405067..2405930 - 864 WP_001267508.1 neutral zinc metallopeptidase -
H1C97_RS11625 2406077..2406475 - 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
H1C97_RS11630 2406475..2406702 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H1C97_RS11635 2406856..2407569 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H1C97_RS11640 2407782..2408816 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
H1C97_RS11645 2408833..2409711 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H1C97_RS11650 2409857..2410429 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H1C97_RS11655 2410429..2410899 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T289271 WP_000911330.1 NZ_LR778151:c2406475-2406077 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289271 WP_000450524.1 NZ_LR778151:c2406702-2406475 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References