Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1433813..1434339 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H1C97_RS06865 Protein ID WP_000323025.1
Coordinates 1433813..1434100 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H1C97_RS06870 Protein ID WP_000534858.1
Coordinates 1434100..1434339 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS06820 1428837..1429052 - 216 WP_000839590.1 phage lysis protein EssD -
H1C97_RS06825 1429806..1430021 - 216 WP_000066484.1 cold shock-like protein CspB -
H1C97_RS06830 1430322..1430534 + 213 WP_000087756.1 cold shock-like protein CspF -
H1C97_RS06835 1430589..1430678 + 90 WP_120795389.1 hypothetical protein -
H1C97_RS06840 1430956..1431708 - 753 WP_001047135.1 antitermination protein -
H1C97_RS06845 1431722..1432771 - 1050 WP_001265199.1 DUF968 domain-containing protein -
H1C97_RS06850 1432773..1433051 - 279 WP_012304870.1 hypothetical protein -
H1C97_RS06855 1433118..1433369 - 252 WP_000980994.1 hypothetical protein -
H1C97_RS06860 1433586..1433741 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
H1C97_RS06865 1433813..1434100 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H1C97_RS06870 1434100..1434339 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H1C97_RS06875 1434364..1434669 + 306 WP_001326990.1 hypothetical protein -
H1C97_RS06880 1434872..1435204 + 333 WP_001301033.1 protein FlxA -
H1C97_RS06885 1435641..1436981 - 1341 WP_000589012.1 ISNCY family transposase -
H1C97_RS06890 1437015..1437434 - 420 WP_001151195.1 DUF977 family protein -
H1C97_RS06895 1437475..1438440 - 966 WP_000054504.1 hypothetical protein -
H1C97_RS06900 1438421..1438942 - 522 WP_000705349.1 hypothetical protein -
H1C97_RS06905 1438926..1439153 - 228 WP_000476993.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1398333..1445544 47211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289265 WP_000323025.1 NZ_LR778151:c1434100-1433813 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289265 WP_000534858.1 NZ_LR778151:c1434339-1434100 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References