289261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 269483..270320 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag H1C97_RS01340 Protein ID WP_000227784.1
Coordinates 269483..270025 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID -
Locus tag H1C97_RS01345 Protein ID WP_112029056.1
Coordinates 270009..270320 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS01320 265021..265932 - 912 WP_000705874.1 2-dehydropantoate 2-reductase -
H1C97_RS01325 266100..266591 + 492 WP_001138904.1 nucleotide binding protein YajQ -
H1C97_RS01330 266719..268083 - 1365 WP_044687660.1 MFS transporter -
H1C97_RS01335 268522..269427 + 906 Protein_258 sel1 repeat family protein -
H1C97_RS01340 269483..270025 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
H1C97_RS01345 270009..270320 - 312 WP_112029056.1 DUF1778 domain-containing protein Antitoxin
H1C97_RS01350 270505..271395 - 891 WP_000971336.1 heme o synthase -
H1C97_RS01355 271407..271736 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
H1C97_RS01360 271736..272350 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
H1C97_RS01365 272340..274331 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
H1C97_RS01370 274353..275300 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T289261 WP_000227784.1 NZ_LR778151:c270025-269483 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11348.00 Da        Isoelectric Point: 10.4825

>AT289261 WP_112029056.1 NZ_LR778151:c270320-270009 [Escherichia coli]
MPGKTATLSDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure

References