Detailed information of TA system TA028926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 1969744..1970731
• Replicon: chromosome
• Accession: NC_020246
• Organism: Sulfolobus acidocaldarius N8

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M1IU00
• Locus tag: SACN8_RS10335
• Protein ID: WP_011278971.1
• Coordinates: 1969744..1970361 (-)
• Length: 206 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I835
• Locus tag: SACN8_RS10340
• Protein ID: WP_011278972.1
• Coordinates: 1970387..1970731 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SACN8_RS10320 (SacN8_10615)	1965347..1965949	+	603	WP_011278968.1	hypothetical protein	-
SACN8_RS10325 (SacN8_10620)	1966001..1967392	-	1392	WP_015385787.1	APC family permease	-
SACN8_RS10330 (SacN8_10625)	1967543..1969537	+	1995	WP_011278970.1	primary-amine oxidase	-
SACN8_RS10335 (SacN8_10630)	1969744..1970361	-	618	WP_011278971.1	helix-turn-helix domain-containing protein	Toxin
SACN8_RS10340 (SacN8_10635)	1970387..1970731	-	345	WP_011278972.1	DUF488 domain-containing protein	Antitoxin
SACN8_RS10345 (SacN8_10640)	1971037..1971825	+	789	WP_011278973.1	aldose 1-epimerase	-
SACN8_RS10350 (SacN8_10645)	1972123..1973133	+	1011	WP_011278974.1	NAD-binding protein	-
SACN8_RS10355 (SacN8_10650)	1973721..1974350	-	630	WP_011278975.1	amidohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (146-196)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 206 a.a.
• Molecular weight: 23779.04 Da
• Isoelectric Point: 9.9689

>T28926 WP_011278971.1 NC_020246:c1970361-1969744 [Sulfolobus acidocaldarius N8]
MVFASKRPIEVTLLVDKHPCEVLDIFRKYEIKAQITNVKLRDQVTDHIAFLKINDDILKELKRRSLKTLRINENTIWIRT
NGCGVCKLLYHSDLIVEKVKVLSKATVMYKLLLPNLSALKQFLEELNSIRVEATVANVSEIDESELTDRQLEILRLAYKS
GYFDVDRKISMKELANKLGIKASTLEEILRRALKKAVKYYLDRKS

Nucleotide

• Length: 618 bp

>T28926 NC_020246:c1970361-1969744 [Sulfolobus acidocaldarius N8]
ATGGTCTTTGCCTCAAAGAGACCCATTGAAGTTACACTCCTAGTGGATAAACACCCATGCGAAGTCTTAGACATATTTAG
AAAATATGAAATTAAGGCTCAGATAACTAATGTTAAGCTAAGGGATCAGGTTACTGACCATATTGCATTCCTTAAGATAA
ACGATGATATACTCAAGGAATTAAAGAGAAGGTCTCTTAAAACTTTAAGGATAAATGAAAATACCATTTGGATAAGGACA
AACGGTTGCGGCGTTTGTAAACTACTCTATCACTCTGACCTAATTGTGGAAAAGGTAAAGGTGTTAAGTAAAGCTACTGT
TATGTATAAACTTCTATTACCAAATCTTTCTGCATTGAAACAGTTTTTAGAAGAACTGAACAGCATAAGAGTAGAGGCTA
CAGTTGCCAATGTATCAGAAATTGACGAGAGCGAGTTAACAGATAGACAATTGGAAATCCTGAGATTGGCTTACAAATCA
GGCTATTTTGATGTCGATAGGAAAATCTCGATGAAGGAATTAGCCAATAAATTGGGGATAAAGGCATCTACGCTAGAGGA
GATACTGAGGAGGGCTCTAAAAAAGGCTGTAAAATATTATTTGGACAGAAAGAGCTAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13706.92 Da
• Isoelectric Point: 9.2564

>AT28926 WP_011278972.1 NC_020246:c1970731-1970387 [Sulfolobus acidocaldarius N8]
MIKVKRVYDAPESDDGVRILIDRLWPRGVKKDLVDIWMKDIAPSDELRKWFNHEPEKWEEFKHKYMEELRSNPKVKVLIE
VIRRSENVTFLYATKSPYNNAVVLKEYIESLLTK

Nucleotide

• Length: 345 bp

>AT28926 NC_020246:c1970731-1970387 [Sulfolobus acidocaldarius N8]
ATGATTAAGGTCAAGCGAGTTTATGACGCACCTGAATCTGATGATGGGGTCAGAATATTGATTGACCGATTATGGCCTAG
AGGAGTAAAGAAAGATCTAGTGGATATTTGGATGAAAGATATTGCTCCATCAGATGAGTTAAGGAAATGGTTTAATCATG
AACCTGAAAAGTGGGAAGAGTTTAAGCACAAGTATATGGAGGAGCTTAGAAGTAACCCTAAGGTCAAAGTCTTAATCGAG
GTAATAAGGAGAAGCGAAAATGTTACATTCCTATATGCCACTAAATCGCCTTACAATAATGCGGTAGTTTTAAAGGAGTA
TATTGAAAGTTTGTTAACAAAATAA

Structures

Toxin

• AlphaFold DB: M1IU00

Antitoxin

• AlphaFold DB: M1I835