Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4389098..4389723 Replicon chromosome
Accession NZ_LR778149
Organism Escherichia coli isolate SC487

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag H1C96_RS21085 Protein ID WP_000911329.1
Coordinates 4389325..4389723 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H1C96_RS21080 Protein ID WP_000450524.1
Coordinates 4389098..4389325 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C96_RS21055 4384900..4385370 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
H1C96_RS21060 4385370..4385942 - 573 WP_097732141.1 glycine cleavage system transcriptional repressor -
H1C96_RS21065 4386088..4386966 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H1C96_RS21070 4386983..4388017 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
H1C96_RS21075 4388230..4388943 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H1C96_RS21080 4389098..4389325 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H1C96_RS21085 4389325..4389723 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
H1C96_RS21090 4389870..4390733 + 864 WP_001267498.1 neutral zinc metallopeptidase -
H1C96_RS21095 4390748..4392763 + 2016 WP_000829293.1 tRNA cytosine(34) acetyltransferase TmcA -
H1C96_RS21100 4392837..4393535 + 699 WP_000679823.1 esterase -
H1C96_RS21105 4393645..4393845 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T289242 WP_000911329.1 NZ_LR778149:4389325-4389723 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289242 WP_000450524.1 NZ_LR778149:4389098-4389325 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References