Detailed information of TA system TA028924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1779618..1780121
• Replicon: chromosome
• Accession: NC_020246
• Organism: Sulfolobus acidocaldarius N8

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SACN8_RS11845
• Protein ID: WP_162465564.1
• Coordinates: 1779966..1780121 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I7E0
• Locus tag: SACN8_RS09520
• Protein ID: WP_011278775.1
• Coordinates: 1779618..1779860 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SACN8_RS09500 (SacN8_09710)	1775130..1776617	+	1488	WP_230949672.1	AMP-binding protein	-
SACN8_RS09505 (SacN8_09715)	1776604..1777722	+	1119	WP_011278772.1	arabinonate dehydratase	-
SACN8_RS09510 (SacN8_09720)	1777724..1778884	+	1161	WP_011278773.1	thiolase family protein	-
SACN8_RS09515 (SacN8_09725)	1778877..1779221	+	345	WP_011278774.1	zinc ribbon domain-containing protein	-
SACN8_RS09520 (SacN8_09730)	1779618..1779860	+	243	WP_011278775.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SACN8_RS11845 (SacN8_09735)	1779966..1780121	+	156	WP_162465564.1	hypothetical protein	Toxin
SACN8_RS09525 (SacN8_09740)	1780580..1781905	+	1326	WP_015385888.1	APC family permease	-
SACN8_RS09530 (SacN8_09745)	1782064..1784310	+	2247	WP_011278777.1	MMPL family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5963.78 Da
• Isoelectric Point: 4.1435

>T28924 WP_162465564.1 NC_020246:1779966-1780121 [Sulfolobus acidocaldarius N8]
VEIAYFLVKNGIEVRSVIESTLSDPKVEVIENILEDLYFAIRSEPRKYDDF

Nucleotide

• Length: 156 bp

>T28924 NC_020246:1779966-1780121 [Sulfolobus acidocaldarius N8]
GTGGAAATTGCTTACTTCTTGGTGAAGAATGGGATTGAAGTCAGGAGCGTCATAGAGAGTACACTCAGTGACCCTAAAGT
GGAAGTTATCGAGAACATCCTTGAGGACTTGTATTTTGCAATAAGGAGTGAGCCAAGAAAATATGATGACTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9009.48 Da
• Isoelectric Point: 8.9835

>AT28924 WP_011278775.1 NC_020246:1779618-1779860 [Sulfolobus acidocaldarius N8]
MFEESRVTRNYRITIPATIRQKLGIRVGDKLIVYTEGDKIILVKKKGDLVSLNLKLGRKFTDEEVNKVIEEAGEEVGGSC

Nucleotide

• Length: 243 bp

>AT28924 NC_020246:1779618-1779860 [Sulfolobus acidocaldarius N8]
ATGTTTGAAGAGAGCAGAGTCACCAGGAATTACCGAATAACAATACCAGCTACTATCAGGCAAAAACTGGGAATCAGGGT
CGGTGATAAACTCATAGTGTATACCGAGGGTGATAAAATAATACTGGTCAAAAAGAAGGGTGACTTAGTGTCCTTAAACC
TAAAGTTAGGTAGGAAGTTTACTGATGAAGAGGTCAATAAAGTAATAGAGGAAGCAGGAGAGGAAGTTGGAGGGAGTTGT
TGA

Structures

Antitoxin

• AlphaFold DB: M1I7E0