Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 3369600..3370231 | Replicon | chromosome |
Accession | NZ_LR778149 | ||
Organism | Escherichia coli isolate SC487 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | F4NNK6 |
Locus tag | H1C96_RS16075 | Protein ID | WP_001259388.1 |
Coordinates | 3369600..3369875 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | U9Y7E1 |
Locus tag | H1C96_RS16080 | Protein ID | WP_000593555.1 |
Coordinates | 3369872..3370231 (+) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H1C96_RS16060 | 3364604..3365671 | + | 1068 | WP_000361467.1 | HlyD family secretion protein | - |
H1C96_RS16065 | 3365668..3368403 | + | 2736 | WP_000149124.1 | ribosome-associated ATPase/putative transporter RbbA | - |
H1C96_RS16070 | 3368403..3369527 | + | 1125 | WP_001216257.1 | ABC transporter permease | - |
H1C96_RS16075 | 3369600..3369875 | + | 276 | WP_001259388.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
H1C96_RS16080 | 3369872..3370231 | + | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
H1C96_RS16085 | 3370351..3370752 | - | 402 | WP_001190062.1 | nickel-responsive transcriptional regulator NikR | - |
H1C96_RS16090 | 3370758..3371564 | - | 807 | WP_000173666.1 | nickel import ATP-binding protein NikE | - |
H1C96_RS16095 | 3371561..3372325 | - | 765 | WP_001136236.1 | nickel import ATP-binding protein NikD | - |
H1C96_RS16100 | 3372325..3373158 | - | 834 | WP_001008963.1 | nickel ABC transporter permease subunit NikC | - |
H1C96_RS16105 | 3373155..3374099 | - | 945 | WP_000947068.1 | nickel ABC transporter permease subunit NikB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 3362616..3370752 | 8136 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A0FFA2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LKZ6 |