Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 3369600..3370231 Replicon chromosome
Accession NZ_LR778149
Organism Escherichia coli isolate SC487

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag H1C96_RS16075 Protein ID WP_001259388.1
Coordinates 3369600..3369875 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag H1C96_RS16080 Protein ID WP_000593555.1
Coordinates 3369872..3370231 (+) Length 120 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C96_RS16060 3364604..3365671 + 1068 WP_000361467.1 HlyD family secretion protein -
H1C96_RS16065 3365668..3368403 + 2736 WP_000149124.1 ribosome-associated ATPase/putative transporter RbbA -
H1C96_RS16070 3368403..3369527 + 1125 WP_001216257.1 ABC transporter permease -
H1C96_RS16075 3369600..3369875 + 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
H1C96_RS16080 3369872..3370231 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1C96_RS16085 3370351..3370752 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
H1C96_RS16090 3370758..3371564 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
H1C96_RS16095 3371561..3372325 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
H1C96_RS16100 3372325..3373158 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
H1C96_RS16105 3373155..3374099 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3362616..3370752 8136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-80)

Antitoxin

(60-112)


Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T289238 WP_001259388.1 NZ_LR778149:3369600-3369875 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp


Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT289238 WP_000593555.1 NZ_LR778149:3369872-3370231 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References