Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4594790..4595415 Replicon chromosome
Accession NZ_LR778148
Organism Escherichia coli isolate SC475

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag H1C74_RS21960 Protein ID WP_000911329.1
Coordinates 4594790..4595188 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H1C74_RS21965 Protein ID WP_000450524.1
Coordinates 4595188..4595415 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C74_RS21940 4590668..4590868 + 201 WP_000383836.1 YpfN family protein -
H1C74_RS21945 4590978..4591676 - 699 WP_000679823.1 esterase -
H1C74_RS21950 4591750..4593765 - 2016 WP_000829293.1 tRNA cytosine(34) acetyltransferase TmcA -
H1C74_RS21955 4593780..4594643 - 864 WP_001267498.1 neutral zinc metallopeptidase -
H1C74_RS21960 4594790..4595188 - 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
H1C74_RS21965 4595188..4595415 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H1C74_RS21970 4595570..4596283 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H1C74_RS21975 4596496..4597530 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
H1C74_RS21980 4597547..4598425 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H1C74_RS21985 4598571..4599143 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H1C74_RS21990 4599143..4599613 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T289226 WP_000911329.1 NZ_LR778148:c4595188-4594790 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289226 WP_000450524.1 NZ_LR778148:c4595415-4595188 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References