Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3646952..3647478 Replicon chromosome
Accession NZ_LR778148
Organism Escherichia coli isolate SC475

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H1C74_RS17400 Protein ID WP_000323025.1
Coordinates 3646952..3647239 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H1C74_RS17405 Protein ID WP_000534858.1
Coordinates 3647239..3647478 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C74_RS17355 3641976..3642191 - 216 WP_000839590.1 phage lysis protein EssD -
H1C74_RS17360 3642945..3643160 - 216 WP_000066484.1 cold shock-like protein CspB -
H1C74_RS17365 3643461..3643673 + 213 WP_000087756.1 cold shock-like protein CspF -
H1C74_RS17370 3643728..3643817 + 90 WP_120795389.1 hypothetical protein -
H1C74_RS17375 3644095..3644847 - 753 WP_001047135.1 antitermination protein -
H1C74_RS17380 3644861..3645910 - 1050 WP_001265198.1 DUF968 domain-containing protein -
H1C74_RS17385 3645912..3646190 - 279 WP_012304870.1 hypothetical protein -
H1C74_RS17390 3646257..3646508 - 252 WP_000980994.1 hypothetical protein -
H1C74_RS17395 3646725..3646880 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
H1C74_RS17400 3646952..3647239 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H1C74_RS17405 3647239..3647478 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H1C74_RS17410 3647503..3647808 + 306 WP_071527819.1 hypothetical protein -
H1C74_RS17415 3648011..3648343 + 333 WP_001317460.1 FlxA-like family protein -
H1C74_RS17420 3648780..3650120 - 1341 WP_042054313.1 ISNCY family transposase -
H1C74_RS17425 3650154..3650573 - 420 WP_001151196.1 DUF977 family protein -
H1C74_RS17430 3650614..3651579 - 966 WP_000054504.1 hypothetical protein -
H1C74_RS17435 3651560..3652081 - 522 WP_000705349.1 hypothetical protein -
H1C74_RS17440 3652065..3652292 - 228 WP_000476993.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3604816..3659976 55160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289220 WP_000323025.1 NZ_LR778148:c3647239-3646952 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289220 WP_000534858.1 NZ_LR778148:c3647478-3647239 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References