Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3462276..3462914 Replicon chromosome
Accession NZ_LR778148
Organism Escherichia coli isolate SC475

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H1C74_RS16535 Protein ID WP_000813794.1
Coordinates 3462276..3462452 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H1C74_RS16540 Protein ID WP_001270286.1
Coordinates 3462498..3462914 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C74_RS16515 3457895..3459109 - 1215 WP_001326689.1 BenE family transporter YdcO -
H1C74_RS16520 3459162..3459698 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
H1C74_RS16525 3459771..3461732 + 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H1C74_RS16530 3461824..3462054 - 231 WP_000494244.1 YncJ family protein -
H1C74_RS16535 3462276..3462452 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H1C74_RS16540 3462498..3462914 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H1C74_RS16545 3462993..3464399 + 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
H1C74_RS16550 3464644..3465789 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
H1C74_RS16555 3465807..3466820 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
H1C74_RS16560 3466821..3467762 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3456707..3457855 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T289218 WP_000813794.1 NZ_LR778148:3462276-3462452 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT289218 WP_001270286.1 NZ_LR778148:3462498-3462914 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References