Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 1641978..1642475 Replicon chromosome
Accession NZ_LR778148
Organism Escherichia coli isolate SC475

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag H1C74_RS07825 Protein ID WP_001173343.1
Coordinates 1642302..1642475 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A793CJD6
Locus tag H1C74_RS07820 Protein ID WP_072057288.1
Coordinates 1641978..1642274 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C74_RS07800 1638709..1639428 - 720 WP_000611288.1 two-component system response regulator DcuR -
H1C74_RS07805 1639425..1641056 - 1632 WP_001216460.1 sensor histidine kinase -
H1C74_RS07810 1641237..1641467 + 231 WP_000371700.1 (4Fe-4S)-binding protein -
H1C74_RS07815 1641479..1641751 + 273 WP_000405647.1 N-acetyltransferase -
H1C74_RS07820 1641978..1642274 + 297 WP_072057288.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
H1C74_RS07825 1642302..1642475 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
H1C74_RS07830 1642594..1644111 - 1518 WP_001295074.1 lysine--tRNA ligase -
H1C74_RS07835 1644348..1645805 - 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T289215 WP_001173343.1 NZ_LR778148:1642302-1642475 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2404

>AT289215 WP_072057288.1 NZ_LR778148:1641978-1642274 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADQYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A793CJD6

References