Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 885369..886000 Replicon chromosome
Accession NZ_LR778148
Organism Escherichia coli isolate SC475

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag H1C74_RS04415 Protein ID WP_001259388.1
Coordinates 885725..886000 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag H1C74_RS04410 Protein ID WP_000593555.1
Coordinates 885369..885728 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C74_RS04385 881501..882445 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
H1C74_RS04390 882442..883275 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
H1C74_RS04395 883275..884039 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
H1C74_RS04400 884036..884842 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
H1C74_RS04405 884848..885249 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
H1C74_RS04410 885369..885728 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1C74_RS04415 885725..886000 - 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
H1C74_RS04420 886073..887197 - 1125 WP_001216257.1 ABC transporter permease -
H1C74_RS04425 887197..889932 - 2736 WP_000149124.1 ribosome-associated ATPase/putative transporter RbbA -
H1C74_RS04430 889929..890996 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T289213 WP_001259388.1 NZ_LR778148:c886000-885725 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT289213 WP_000593555.1 NZ_LR778148:c885728-885369 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References