Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5043047..5043642 Replicon chromosome
Accession NZ_LR778147
Organism Escherichia coli isolate SC418

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag H1D11_RS23850 Protein ID WP_000239581.1
Coordinates 5043047..5043397 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID V0YZQ7
Locus tag H1D11_RS23855 Protein ID WP_001223206.1
Coordinates 5043391..5043642 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D11_RS23830 5038501..5039523 - 1023 WP_001361374.1 ABC transporter permease -
H1D11_RS23835 5039537..5041039 - 1503 WP_115423679.1 sugar ABC transporter ATP-binding protein -
H1D11_RS23840 5041172..5042128 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H1D11_RS23845 5042438..5042968 + 531 WP_000055075.1 inorganic diphosphatase -
H1D11_RS23850 5043047..5043397 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
H1D11_RS23855 5043391..5043642 - 252 WP_001223206.1 type II toxin-antitoxin system ChpS family antitoxin Antitoxin
H1D11_RS23860 5043854..5044195 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H1D11_RS23865 5044198..5047978 - 3781 Protein_4653 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T289209 WP_000239581.1 NZ_LR778147:c5043397-5043047 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9303.62 Da        Isoelectric Point: 4.6509

>AT289209 WP_001223206.1 NZ_LR778147:c5043642-5043391 [Escherichia coli]
MRITIKKWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB V0YZQ7

References