Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 4373311..4374148 Replicon chromosome
Accession NZ_LR778147
Organism Escherichia coli isolate SC418

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag H1D11_RS20850 Protein ID WP_115423549.1
Coordinates 4373606..4374148 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A0A080JFU1
Locus tag H1D11_RS20845 Protein ID WP_001577859.1
Coordinates 4373311..4373622 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D11_RS20820 4368331..4369278 + 948 WP_001239436.1 cytochrome o ubiquinol oxidase subunit II -
H1D11_RS20825 4369300..4371291 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
H1D11_RS20830 4371281..4371895 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
H1D11_RS20835 4371895..4372224 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
H1D11_RS20840 4372236..4373126 + 891 WP_115423548.1 heme o synthase -
H1D11_RS20845 4373311..4373622 + 312 WP_001577859.1 DUF1778 domain-containing protein Antitoxin
H1D11_RS20850 4373606..4374148 + 543 WP_115423549.1 GNAT family N-acetyltransferase Toxin
H1D11_RS20855 4374204..4375139 - 936 WP_077250576.1 sel1 repeat family protein -
H1D11_RS20860 4375546..4376910 + 1365 WP_001000953.1 MFS transporter -
H1D11_RS20865 4377038..4377529 - 492 WP_001138904.1 nucleotide binding protein YajQ -
H1D11_RS20870 4377697..4378608 + 912 WP_115423551.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(65-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19822.99 Da        Isoelectric Point: 8.3395

>T289205 WP_115423549.1 NZ_LR778147:4373606-4374148 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRTSLKKSVRNSDCAAKALIDRQSGELIGTCTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11400.08 Da        Isoelectric Point: 10.5548

>AT289205 WP_001577859.1 NZ_LR778147:4373311-4373622 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNRLREAAQAVGLDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A080JFU1

References