Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4338511..4339129 Replicon chromosome
Accession NZ_LR778147
Organism Escherichia coli isolate SC418

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H1D11_RS20675 Protein ID WP_001291435.1
Coordinates 4338911..4339129 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H1D11_RS20670 Protein ID WP_000344800.1
Coordinates 4338511..4338885 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D11_RS20660 4333600..4334793 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H1D11_RS20665 4334816..4337965 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
H1D11_RS20670 4338511..4338885 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H1D11_RS20675 4338911..4339129 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
H1D11_RS20680 4339301..4339852 + 552 WP_001522034.1 maltose O-acetyltransferase -
H1D11_RS20685 4339968..4340438 + 471 WP_000136192.1 YlaC family protein -
H1D11_RS20690 4340602..4342152 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H1D11_RS20695 4342194..4342547 - 354 WP_000878140.1 DUF1428 domain-containing protein -
H1D11_RS20705 4342926..4343237 + 312 WP_000409911.1 MGMT family protein -
H1D11_RS20710 4343268..4343840 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T289204 WP_001291435.1 NZ_LR778147:4338911-4339129 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT289204 WP_000344800.1 NZ_LR778147:4338511-4338885 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References