Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3239289..3239927 Replicon chromosome
Accession NZ_LR778147
Organism Escherichia coli isolate SC418

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag H1D11_RS15395 Protein ID WP_000813797.1
Coordinates 3239751..3239927 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H1D11_RS15390 Protein ID WP_076611057.1
Coordinates 3239289..3239705 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D11_RS15370 3234441..3235382 - 942 WP_001251315.1 ABC transporter permease -
H1D11_RS15375 3235383..3236396 - 1014 WP_000220413.1 ABC transporter ATP-binding protein -
H1D11_RS15380 3236414..3237559 - 1146 WP_115423856.1 ABC transporter substrate-binding protein -
H1D11_RS15385 3237804..3239210 - 1407 WP_115423855.1 PLP-dependent aminotransferase family protein -
H1D11_RS15390 3239289..3239705 - 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H1D11_RS15395 3239751..3239927 - 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H1D11_RS15400 3240149..3240379 + 231 WP_000494244.1 YncJ family protein -
H1D11_RS15405 3240471..3242432 - 1962 WP_115423854.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H1D11_RS15410 3242505..3243041 - 537 WP_000429506.1 DNA-binding transcriptional regulator SutR -
H1D11_RS15415 3243094..3244305 + 1212 WP_096132700.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T289202 WP_000813797.1 NZ_LR778147:c3239927-3239751 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT289202 WP_076611057.1 NZ_LR778147:c3239705-3239289 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References