Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1524648..1525302 Replicon chromosome
Accession NZ_LR778147
Organism Escherichia coli isolate SC418

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag H1D11_RS07060 Protein ID WP_000244781.1
Coordinates 1524895..1525302 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag H1D11_RS07055 Protein ID WP_000354046.1
Coordinates 1524648..1524914 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D11_RS07035 1520736..1522169 - 1434 WP_001562037.1 6-phospho-beta-glucosidase BglA -
H1D11_RS07040 1522214..1522525 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
H1D11_RS07045 1522689..1523348 + 660 WP_000250274.1 hemolysin III family protein -
H1D11_RS07050 1523425..1524405 - 981 WP_001587401.1 tRNA-modifying protein YgfZ -
H1D11_RS07055 1524648..1524914 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
H1D11_RS07060 1524895..1525302 + 408 WP_000244781.1 protein YgfX Toxin
H1D11_RS07065 1525342..1525863 - 522 WP_001055874.1 flavodoxin FldB -
H1D11_RS07070 1525975..1526871 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H1D11_RS07075 1526896..1527606 + 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H1D11_RS07080 1527612..1529345 + 1734 WP_115423631.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T289194 WP_000244781.1 NZ_LR778147:1524895-1525302 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT289194 WP_000354046.1 NZ_LR778147:1524648-1524914 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References