Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 802822..803453 Replicon chromosome
Accession NZ_LR778147
Organism Escherichia coli isolate SC418

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag H1D11_RS03520 Protein ID WP_001260301.1
Coordinates 802822..803097 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag H1D11_RS03525 Protein ID WP_000593555.1
Coordinates 803094..803453 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D11_RS03505 797826..798893 + 1068 WP_000361480.1 HlyD family efflux transporter periplasmic adaptor subunit -
H1D11_RS03510 798890..801625 + 2736 WP_000149141.1 ribosome-associated ATPase/putative transporter RbbA -
H1D11_RS03515 801625..802749 + 1125 WP_001314210.1 ABC transporter permease -
H1D11_RS03520 802822..803097 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
H1D11_RS03525 803094..803453 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1D11_RS03530 803503..804363 - 861 WP_024229779.1 class II aldolase -
H1D11_RS03535 804394..804663 - 270 WP_000949583.1 HPr family phosphocarrier protein -
H1D11_RS03540 804653..806161 - 1509 WP_001586380.1 xylulose kinase -
H1D11_RS03545 806154..807512 - 1359 WP_001306345.1 PTS galactitol transporter subunit IIC -
H1D11_RS03550 807589..807870 - 282 WP_000084021.1 PTS sugar transporter subunit IIB -
H1D11_RS03555 807867..808340 - 474 WP_001306344.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T289191 WP_001260301.1 NZ_LR778147:802822-803097 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT289191 WP_000593555.1 NZ_LR778147:803094-803453 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References