Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3763786..3764315 Replicon chromosome
Accession NC_020245
Organism Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag K60_RS17630 Protein ID WP_003417760.1
Coordinates 3764058..3764315 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag K60_RS17625 Protein ID WP_003417757.1
Coordinates 3763786..3764061 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K60_RS17590 3758817..3760115 - 1299 WP_011799343.1 PPE family protein -
K60_RS22635 3760584..3762021 - 1438 Protein_3439 FAD-binding oxidoreductase -
K60_RS17610 3762124..3762513 + 390 WP_010950876.1 DUF732 domain-containing protein -
K60_RS17615 3762527..3762820 - 294 WP_003417749.1 DUF3017 domain-containing protein -
K60_RS17620 3762817..3763662 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
K60_RS17625 3763786..3764061 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
K60_RS17630 3764058..3764315 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
K60_RS17635 3764357..3765547 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
K60_RS17640 3765664..3766032 + 369 WP_003417765.1 FHA domain-containing protein -
K60_RS17645 3766029..3766580 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
K60_RS17650 3766587..3767168 - 582 WP_003417769.1 ATP/GTP-binding protein -
K60_RS17655 3767149..3767517 - 369 WP_003417772.1 DUF742 domain-containing protein -
K60_RS17660 3767495..3767887 - 393 WP_011799344.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T28919 WP_003417760.1 NC_020245:3764058-3764315 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T28919 NC_020245:3764058-3764315 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT28919 WP_003417757.1 NC_020245:3763786-3764061 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT28919 NC_020245:3763786-3764061 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References