Detailed information of TA system TA289188

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2280..3115
• Replicon: chromosome
• Accession: NZ_LR778147
• Organism: Escherichia coli isolate SC418

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H1D11_RS00030
• Protein ID: WP_000854684.1
• Coordinates: 2738..3115 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: H1D11_RS00025
• Protein ID: WP_180349223.1
• Coordinates: 2280..2648 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D11_RS00005	24..842	+	819	WP_001234700.1	DUF945 domain-containing protein	-
H1D11_RS00010	934..1419	+	486	WP_000206667.1	antirestriction protein	-
H1D11_RS00015	1435..1911	+	477	WP_001186711.1	RadC family protein	-
H1D11_RS00020	1980..2201	+	222	WP_000692300.1	DUF987 domain-containing protein	-
H1D11_RS00025	2280..2648	+	369	WP_180349223.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H1D11_RS00030	2738..3115	+	378	WP_000854684.1	TA system toxin CbtA family protein	Toxin
H1D11_RS24720	3112..3291	+	180	Protein_6	hypothetical protein	-
H1D11_RS24725	3340..3534	+	195	WP_032216488.1	DUF957 domain-containing protein	-
H1D11_RS00040	4453..6564	+	2112	Protein_8	autotransporter outer membrane beta-barrel domain-containing protein	-
H1D11_RS00045	6710..7729	+	1020	WP_000878012.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14278.29 Da
• Isoelectric Point: 8.2761

>T289188 WP_000854684.1 NZ_LR778147:2738-3115 [Escherichia coli]
MKTLPDTHIREASRCPSPVTVWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Nucleotide

• Length: 378 bp

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13658.33 Da
• Isoelectric Point: 5.9562

>AT289188 WP_180349223.1 NZ_LR778147:2280-2648 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQDFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKT

Nucleotide

• Length: 369 bp