Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3754616..3755247 Replicon chromosome
Accession NZ_LR778146
Organism Escherichia coli isolate SC455

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag H1D08_RS18105 Protein ID WP_001260301.1
Coordinates 3754616..3754891 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag H1D08_RS18110 Protein ID WP_000593555.1
Coordinates 3754888..3755247 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D08_RS18090 3749620..3750687 + 1068 WP_000361470.1 HlyD family secretion protein -
H1D08_RS18095 3750684..3753419 + 2736 WP_074448880.1 ribosome-associated ATPase/putative transporter RbbA -
H1D08_RS18100 3753419..3754543 + 1125 WP_024231700.1 ABC transporter permease -
H1D08_RS18105 3754616..3754891 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
H1D08_RS18110 3754888..3755247 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1D08_RS18115 3755367..3755768 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
H1D08_RS18120 3755774..3756580 - 807 WP_000173679.1 nickel import ATP-binding protein NikE -
H1D08_RS18125 3756577..3757341 - 765 WP_001136232.1 nickel import ATP-binding protein NikD -
H1D08_RS18130 3757341..3758174 - 834 WP_001008957.1 nickel ABC transporter permease subunit NikC -
H1D08_RS18135 3758171..3759115 - 945 WP_000947070.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T289182 WP_001260301.1 NZ_LR778146:3754616-3754891 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT289182 WP_000593555.1 NZ_LR778146:3754888-3755247 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References