Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2925710..2926207 Replicon chromosome
Accession NZ_LR778146
Organism Escherichia coli isolate SC455

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag H1D08_RS14295 Protein ID WP_001173343.1
Coordinates 2925710..2925883 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag H1D08_RS14300 Protein ID WP_001312331.1
Coordinates 2925911..2926207 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D08_RS14285 2922380..2923837 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
H1D08_RS14290 2924074..2925591 + 1518 WP_000003805.1 lysine--tRNA ligase -
H1D08_RS14295 2925710..2925883 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
H1D08_RS14300 2925911..2926207 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
H1D08_RS14305 2926436..2926708 - 273 WP_000405647.1 N-acetyltransferase -
H1D08_RS14310 2926720..2926950 - 231 WP_000373291.1 (4Fe-4S)-binding protein -
H1D08_RS14315 2927131..2928762 + 1632 WP_001216466.1 sensor histidine kinase -
H1D08_RS14320 2928759..2929478 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T289178 WP_001173343.1 NZ_LR778146:c2925883-2925710 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT289178 WP_001312331.1 NZ_LR778146:c2926207-2925911 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References