Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4478252..4478847 Replicon chromosome
Accession NZ_LR778145
Organism Escherichia coli isolate SC423

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H1C75_RS21335 Protein ID WP_000239579.1
Coordinates 4478252..4478602 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag H1C75_RS21340 Protein ID WP_001223208.1
Coordinates 4478596..4478847 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C75_RS21315 4473698..4474720 - 1023 WP_001356014.1 ABC transporter permease -
H1C75_RS21320 4474734..4476236 - 1503 WP_049032561.1 sugar ABC transporter ATP-binding protein -
H1C75_RS21325 4476376..4477332 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H1C75_RS21330 4477642..4478172 + 531 WP_000055070.1 inorganic diphosphatase -
H1C75_RS21335 4478252..4478602 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H1C75_RS21340 4478596..4478847 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H1C75_RS21345 4479059..4479400 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H1C75_RS21350 4479403..4483182 - 3780 WP_053264521.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T289166 WP_000239579.1 NZ_LR778145:c4478602-4478252 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT289166 WP_001223208.1 NZ_LR778145:c4478847-4478596 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References