Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3106718..3107405 Replicon chromosome
Accession NC_020245
Organism Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FBY8
Locus tag K60_RS14735 Protein ID WP_011799298.1
Coordinates 3106962..3107405 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag K60_RS14730 Protein ID WP_003414620.1
Coordinates 3106718..3106975 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K60_RS14710 3102038..3102892 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
K60_RS14715 3102948..3104111 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
K60_RS14720 3104128..3105342 - 1215 WP_011799297.1 zinc metalloprotease Rip -
K60_RS14725 3105350..3106591 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
K60_RS14730 3106718..3106975 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
K60_RS14735 3106962..3107405 + 444 WP_011799298.1 type II toxin-antitoxin system VapC family toxin Toxin
K60_RS14740 3107485..3108147 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
K60_RS14745 3108243..3108434 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K60_RS14750 3108766..3110514 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
K60_RS14755 3110610..3111191 + 582 WP_003414644.1 fasciclin domain-containing protein -
K60_RS14760 3111291..3111557 + 267 WP_031657293.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16625.74 Da        Isoelectric Point: 6.4890

>T28916 WP_011799298.1 NC_020245:3106962-3107405 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDTLLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T28916 NC_020245:3106962-3107405 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACACCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT28916 WP_003414620.1 NC_020245:3106718-3106975 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT28916 NC_020245:3106718-3106975 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBY8

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References