Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1672801..1673426 Replicon chromosome
Accession NZ_LR778145
Organism Escherichia coli isolate SC423

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag H1C75_RS07945 Protein ID WP_000911329.1
Coordinates 1673028..1673426 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H1C75_RS07940 Protein ID WP_000450524.1
Coordinates 1672801..1673028 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C75_RS07915 1668603..1669073 - 471 WP_089620216.1 thioredoxin-dependent thiol peroxidase -
H1C75_RS07920 1669073..1669645 - 573 WP_000176191.1 glycine cleavage system transcriptional repressor -
H1C75_RS07925 1669791..1670669 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H1C75_RS07930 1670686..1671720 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
H1C75_RS07935 1671933..1672646 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H1C75_RS07940 1672801..1673028 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H1C75_RS07945 1673028..1673426 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
H1C75_RS07950 1673573..1674436 + 864 WP_001267498.1 neutral zinc metallopeptidase -
H1C75_RS07955 1674451..1676466 + 2016 WP_047084717.1 tRNA cytosine(34) acetyltransferase TmcA -
H1C75_RS07960 1676540..1677238 + 699 WP_000679823.1 esterase -
H1C75_RS07965 1677348..1677548 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T289157 WP_000911329.1 NZ_LR778145:1673028-1673426 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289157 WP_000450524.1 NZ_LR778145:1672801-1673028 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References