Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1204111..1204765 Replicon chromosome
Accession NZ_LR778145
Organism Escherichia coli isolate SC423

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag H1C75_RS05755 Protein ID WP_000244781.1
Coordinates 1204358..1204765 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag H1C75_RS05750 Protein ID WP_000354046.1
Coordinates 1204111..1204377 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C75_RS05725 1199280..1200023 + 744 WP_000951961.1 SDR family oxidoreductase -
H1C75_RS05730 1200080..1201513 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
H1C75_RS05735 1201558..1201869 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
H1C75_RS05740 1202033..1202692 + 660 WP_000250274.1 hemolysin III family protein -
H1C75_RS05745 1202888..1203868 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
H1C75_RS05750 1204111..1204377 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
H1C75_RS05755 1204358..1204765 + 408 WP_000244781.1 protein YgfX Toxin
H1C75_RS05760 1204805..1205326 - 522 WP_001055874.1 flavodoxin FldB -
H1C75_RS05765 1205438..1206334 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H1C75_RS05770 1206359..1207069 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H1C75_RS05775 1207075..1208808 + 1734 WP_000813223.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T289155 WP_000244781.1 NZ_LR778145:1204358-1204765 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT289155 WP_000354046.1 NZ_LR778145:1204111-1204377 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References