Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3892479..3893005 Replicon chromosome
Accession NZ_LR778143
Organism Escherichia coli isolate SC422

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H1C98_RS18685 Protein ID WP_000323025.1
Coordinates 3892718..3893005 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H1C98_RS18680 Protein ID WP_000534858.1
Coordinates 3892479..3892718 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C98_RS18655 3887815..3888171 + 357 WP_001315552.1 class I SAM-dependent methyltransferase -
H1C98_RS24105 3888434..3888616 + 183 Protein_3637 hypothetical protein -
H1C98_RS18660 3888782..3889068 + 287 Protein_3638 hypothetical protein -
H1C98_RS18665 3889837..3891177 + 1341 WP_000589013.1 ISNCY family transposase -
H1C98_RS18670 3891614..3891946 - 333 WP_001349760.1 FlxA-like family protein -
H1C98_RS18675 3892149..3892454 - 306 WP_001326990.1 hypothetical protein -
H1C98_RS18680 3892479..3892718 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H1C98_RS18685 3892718..3893005 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H1C98_RS18690 3893077..3893232 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
H1C98_RS18695 3893449..3893700 + 252 WP_000980999.1 hypothetical protein -
H1C98_RS18700 3893767..3894045 + 279 WP_023140913.1 hypothetical protein -
H1C98_RS18705 3894047..3895096 + 1050 WP_001265196.1 DUF968 domain-containing protein -
H1C98_RS18710 3895110..3895862 + 753 WP_001047131.1 antitermination protein -
H1C98_RS18715 3896037..3896239 - 203 Protein_3649 cold shock-like protein CspF -
H1C98_RS18720 3896538..3896753 + 216 WP_000066484.1 cold shock-like protein CspB -
H1C98_RS18725 3897507..3897722 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3867583..3928463 60880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289150 WP_000323025.1 NZ_LR778143:3892718-3893005 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289150 WP_000534858.1 NZ_LR778143:3892479-3892718 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References