Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3101117..3101665 Replicon chromosome
Accession NC_020245
Organism Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag K60_RS14705 Protein ID WP_003414602.1
Coordinates 3101402..3101665 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag K60_RS14700 Protein ID WP_003414599.1
Coordinates 3101117..3101398 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K60_RS14675 3096740..3097597 - 858 WP_003899513.1 type I methionyl aminopeptidase -
K60_RS14680 3097639..3098223 - 585 WP_010950792.1 DUF1707 domain-containing protein -
K60_RS14685 3098327..3098575 + 249 WP_003913411.1 antitoxin VapB23 -
K60_RS14690 3098572..3098952 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
K60_RS14695 3099034..3100845 - 1812 WP_003414596.1 penicillin-binding protein -
K60_RS14700 3101117..3101398 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
K60_RS14705 3101402..3101665 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K60_RS14710 3102038..3102892 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
K60_RS14715 3102948..3104111 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
K60_RS14720 3104128..3105342 - 1215 WP_011799297.1 zinc metalloprotease Rip -
K60_RS14725 3105350..3106591 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T28915 WP_003414602.1 NC_020245:3101402-3101665 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T28915 NC_020245:3101402-3101665 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT28915 WP_003414599.1 NC_020245:3101117-3101398 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT28915 NC_020245:3101117-3101398 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References