Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2969125..2969750 Replicon chromosome
Accession NZ_LR778143
Organism Escherichia coli isolate SC422

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1C98_RS14255 Protein ID WP_000911330.1
Coordinates 2969352..2969750 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H1C98_RS14250 Protein ID WP_000450524.1
Coordinates 2969125..2969352 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C98_RS14225 2964928..2965398 - 471 WP_001068677.1 thioredoxin-dependent thiol peroxidase -
H1C98_RS14230 2965398..2965970 - 573 WP_000176191.1 glycine cleavage system transcriptional repressor -
H1C98_RS14235 2966116..2966994 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H1C98_RS14240 2967011..2968045 + 1035 WP_001358397.1 outer membrane protein assembly factor BamC -
H1C98_RS14245 2968258..2968971 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H1C98_RS14250 2969125..2969352 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H1C98_RS14255 2969352..2969750 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
H1C98_RS14260 2969897..2970760 + 864 WP_001267508.1 neutral zinc metallopeptidase -
H1C98_RS14265 2970775..2972790 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
H1C98_RS14270 2972864..2973562 + 699 WP_000679823.1 esterase -
H1C98_RS14275 2973672..2973872 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T289144 WP_000911330.1 NZ_LR778143:2969352-2969750 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289144 WP_000450524.1 NZ_LR778143:2969125-2969352 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References