Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2331045..2331880 Replicon chromosome
Accession NZ_LR778143
Organism Escherichia coli isolate SC422

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1L4J186
Locus tag H1C98_RS11115 Protein ID WP_000854742.1
Coordinates 2331045..2331422 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L4J164
Locus tag H1C98_RS11120 Protein ID WP_001406130.1
Coordinates 2331512..2331880 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C98_RS11105 2330351..2330548 - 198 WP_000839267.1 DUF957 domain-containing protein -
H1C98_RS11110 2330560..2331048 - 489 WP_000777551.1 hypothetical protein -
H1C98_RS11115 2331045..2331422 - 378 WP_000854742.1 TA system toxin CbtA family protein Toxin
H1C98_RS11120 2331512..2331880 - 369 WP_001406130.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H1C98_RS11125 2332043..2332264 - 222 WP_000692345.1 DUF987 domain-containing protein -
H1C98_RS11130 2332333..2332809 - 477 WP_001186725.1 RadC family protein -
H1C98_RS11135 2332825..2333310 - 486 WP_000849582.1 antirestriction protein -
H1C98_RS11140 2333365..2334183 - 819 WP_001234648.1 DUF945 domain-containing protein -
H1C98_RS11145 2334283..2334516 - 234 WP_001119729.1 DUF905 family protein -
H1C98_RS11150 2334595..2335050 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14236.28 Da        Isoelectric Point: 8.2976

>T289141 WP_000854742.1 NZ_LR778143:c2331422-2331045 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTHSQLINSIDILRARRATGLMTRSNYRMVNDITRGKHSEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13717.53 Da        Isoelectric Point: 7.0269

>AT289141 WP_001406130.1 NZ_LR778143:c2331880-2331512 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4J186

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4J164

References