Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1556771..1557606 Replicon chromosome
Accession NZ_LR778143
Organism Escherichia coli isolate SC422

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag H1C98_RS07400 Protein ID WP_085447097.1
Coordinates 1556771..1557148 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag H1C98_RS07405 Protein ID WP_115425271.1
Coordinates 1557238..1557606 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C98_RS07380 1551982..1552083 - 102 Protein_1431 DUF4942 domain-containing protein -
H1C98_RS07385 1552391..1555435 - 3045 WP_089592676.1 autotransporter outer membrane beta-barrel domain-containing protein -
H1C98_RS07390 1556352..1556549 - 198 WP_089581460.1 DUF957 domain-containing protein -
H1C98_RS07395 1556577..1556774 - 198 Protein_1434 hypothetical protein -
H1C98_RS07400 1556771..1557148 - 378 WP_085447097.1 type IV toxin-antitoxin system toxin CbtA Toxin
H1C98_RS07405 1557238..1557606 - 369 WP_115425271.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
H1C98_RS07410 1557680..1557901 - 222 WP_000692323.1 DUF987 domain-containing protein -
H1C98_RS07415 1557964..1558440 - 477 WP_001186773.1 RadC family protein -
H1C98_RS07420 1558456..1558941 - 486 WP_174490312.1 antirestriction protein -
H1C98_RS07425 1559033..1559851 - 819 WP_115425206.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeC / faeD / faeE / faeF / faeH / faeI / faeJ 1552391..1594832 42441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14101.24 Da        Isoelectric Point: 8.5162

>T289138 WP_085447097.1 NZ_LR778143:c1557148-1556771 [Escherichia coli]
MKTLPVLPGQAVSSRLSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEVKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13562.36 Da        Isoelectric Point: 5.5269

>AT289138 WP_115425271.1 NZ_LR778143:c1557606-1557238 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References