Detailed information of TA system TA289135

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1007508..1008343
• Replicon: chromosome
• Accession: NZ_LR778143
• Organism: Escherichia coli isolate SC422

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H1C98_RS04905
• Protein ID: WP_061356574.1
• Coordinates: 1007966..1008343 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: H1C98_RS04900
• Protein ID: WP_061356575.1
• Coordinates: 1007508..1007876 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1C98_RS04860	1002787..1003467	+	681	WP_001282912.1	WYL domain-containing protein	-
H1C98_RS04865	1003618..1004295	+	678	WP_001097567.1	hypothetical protein	-
H1C98_RS04870	1004301..1004534	+	234	WP_001278282.1	DUF905 family protein	-
H1C98_RS04875	1004624..1005442	+	819	WP_115425218.1	DUF945 domain-containing protein	-
H1C98_RS04880	1005534..1006019	+	486	WP_000213706.1	antirestriction protein	-
H1C98_RS04885	1006034..1006510	+	477	WP_143370560.1	RadC family protein	-
H1C98_RS04890	1006573..1006794	+	222	WP_061356703.1	DUF987 domain-containing protein	-
H1C98_RS04895	1006813..1007458	+	646	Protein_961	antitoxin of toxin-antitoxin stability system	-
H1C98_RS04900	1007508..1007876	+	369	WP_061356575.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H1C98_RS04905	1007966..1008343	+	378	WP_061356574.1	type IV toxin-antitoxin system toxin CbtA	Toxin
H1C98_RS04910	1008340..1008828	+	489	WP_097743434.1	hypothetical protein	-
H1C98_RS04915	1008848..1009045	+	198	WP_097743433.1	DUF957 domain-containing protein	-
H1C98_RS04920	1009130..1009975	+	846	WP_097743432.1	DUF4942 domain-containing protein	-
H1C98_RS04925	1010046..1011582	+	1537	Protein_967	EAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13988.94 Da
• Isoelectric Point: 7.8847

>T289135 WP_061356574.1 NZ_LR778143:1007966-1008343 [Escherichia coli]
MNTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITSGKHPEAKR

Nucleotide

• Length: 378 bp

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13602.30 Da
• Isoelectric Point: 5.9582

>AT289135 WP_061356575.1 NZ_LR778143:1007508-1007876 [Escherichia coli]
VSDTLSGTTHPDDNNERPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp