Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1668145..1668929 Replicon chromosome
Accession NZ_LR778142
Organism Escherichia coli isolate SC434

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag H1D10_RS08205 Protein ID WP_000613626.1
Coordinates 1668145..1668639 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B1LI61
Locus tag H1D10_RS08210 Protein ID WP_001110446.1
Coordinates 1668636..1668929 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D10_RS08185 1663338..1664435 + 1098 WP_000589300.1 flagellar basal body P-ring protein FlgI -
H1D10_RS08190 1664435..1665376 + 942 WP_001337731.1 flagellar assembly peptidoglycan hydrolase FlgJ -
H1D10_RS08195 1665442..1667085 + 1644 WP_053898721.1 flagellar hook-associated protein FlgK -
H1D10_RS08200 1667097..1668050 + 954 WP_001212764.1 flagellar hook-associated protein FlgL -
H1D10_RS08205 1668145..1668639 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
H1D10_RS08210 1668636..1668929 - 294 WP_001110446.1 DUF1778 domain-containing protein Antitoxin
H1D10_RS08215 1669063..1672248 - 3186 WP_097447887.1 ribonuclease E -
H1D10_RS08220 1672821..1673780 + 960 WP_000846343.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T289115 WP_000613626.1 NZ_LR778142:c1668639-1668145 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11079.67 Da        Isoelectric Point: 10.5423

>AT289115 WP_001110446.1 NZ_LR778142:c1668929-1668636 [Escherichia coli]
MPAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G775

References