Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 973135..973753 Replicon chromosome
Accession NZ_LR778142
Organism Escherichia coli isolate SC434

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H1D10_RS04635 Protein ID WP_001291435.1
Coordinates 973135..973353 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H1D10_RS04640 Protein ID WP_000344800.1
Coordinates 973379..973753 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D10_RS04600 968423..968995 + 573 WP_000779831.1 YbaY family lipoprotein -
H1D10_RS04605 969026..969337 - 312 WP_000409908.1 MGMT family protein -
H1D10_RS04615 969716..970069 + 354 WP_000878140.1 DUF1428 domain-containing protein -
H1D10_RS04620 970111..971661 - 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H1D10_RS04625 971825..972295 - 471 WP_000136192.1 YlaC family protein -
H1D10_RS04630 972411..972962 - 552 WP_000102539.1 maltose O-acetyltransferase -
H1D10_RS04635 973135..973353 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
H1D10_RS04640 973379..973753 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H1D10_RS04645 974299..977448 - 3150 WP_180349099.1 efflux RND transporter permease AcrB -
H1D10_RS04650 977471..978664 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T289114 WP_001291435.1 NZ_LR778142:c973353-973135 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT289114 WP_000344800.1 NZ_LR778142:c973753-973379 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References