Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 200951..201448 Replicon chromosome
Accession NZ_LR778142
Organism Escherichia coli isolate SC434

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag H1D10_RS00915 Protein ID WP_001173343.1
Coordinates 201275..201448 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag H1D10_RS00910 Protein ID WP_001312331.1
Coordinates 200951..201247 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D10_RS00890 197680..198399 - 720 WP_000611291.1 two-component system response regulator DcuR -
H1D10_RS00895 198396..200027 - 1632 WP_001216466.1 sensor histidine kinase -
H1D10_RS00900 200208..200438 + 231 WP_000373291.1 (4Fe-4S)-binding protein -
H1D10_RS00905 200450..200722 + 273 WP_000405647.1 N-acetyltransferase -
H1D10_RS00910 200951..201247 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
H1D10_RS00915 201275..201448 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
H1D10_RS00920 201567..203084 - 1518 WP_000003805.1 lysine--tRNA ligase -
H1D10_RS00925 203321..204778 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T289111 WP_001173343.1 NZ_LR778142:201275-201448 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT289111 WP_001312331.1 NZ_LR778142:200951-201247 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References