Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4106557..4107392 | Replicon | chromosome |
| Accession | NZ_LR778141 | ||
| Organism | Escherichia coli isolate SC407 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | H1C92_RS19885 | Protein ID | WP_061356574.1 |
| Coordinates | 4106557..4106934 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | H1C92_RS19890 | Protein ID | WP_061356575.1 |
| Coordinates | 4107024..4107392 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1C92_RS19865 | 4103318..4104854 | - | 1537 | Protein_3868 | EAL domain-containing protein | - |
| H1C92_RS19870 | 4104925..4105770 | - | 846 | WP_097743432.1 | DUF4942 domain-containing protein | - |
| H1C92_RS19875 | 4105855..4106052 | - | 198 | WP_097743433.1 | DUF957 domain-containing protein | - |
| H1C92_RS19880 | 4106072..4106560 | - | 489 | WP_097743434.1 | hypothetical protein | - |
| H1C92_RS19885 | 4106557..4106934 | - | 378 | WP_061356574.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| H1C92_RS19890 | 4107024..4107392 | - | 369 | WP_061356575.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H1C92_RS19895 | 4107442..4108087 | - | 646 | Protein_3874 | antitoxin of toxin-antitoxin stability system | - |
| H1C92_RS19900 | 4108106..4108327 | - | 222 | WP_061356703.1 | DUF987 domain-containing protein | - |
| H1C92_RS19905 | 4108390..4108866 | - | 477 | WP_143370560.1 | RadC family protein | - |
| H1C92_RS19910 | 4108881..4109366 | - | 486 | WP_000213706.1 | antirestriction protein | - |
| H1C92_RS19915 | 4109458..4110276 | - | 819 | WP_115425218.1 | DUF945 domain-containing protein | - |
| H1C92_RS19920 | 4110366..4110599 | - | 234 | WP_001278282.1 | DUF905 family protein | - |
| H1C92_RS19925 | 4110605..4111282 | - | 678 | WP_001097567.1 | hypothetical protein | - |
| H1C92_RS19930 | 4111433..4112113 | - | 681 | WP_001282912.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13988.94 Da Isoelectric Point: 7.8847
>T289106 WP_061356574.1 NZ_LR778141:c4106934-4106557 [Escherichia coli]
MNTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITSGKHPEAKR
MNTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITSGKHPEAKR
Download Length: 378 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13602.30 Da Isoelectric Point: 5.9582
>AT289106 WP_061356575.1 NZ_LR778141:c4107392-4107024 [Escherichia coli]
VSDTLSGTTHPDDNNERPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNNERPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|