Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4093164..4093661 Replicon chromosome
Accession NZ_LR778141
Organism Escherichia coli isolate SC407

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag H1C92_RS19835 Protein ID WP_001173343.1
Coordinates 4093488..4093661 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag H1C92_RS19830 Protein ID WP_000398619.1
Coordinates 4093164..4093460 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C92_RS19810 4089895..4090614 - 720 WP_000611288.1 two-component system response regulator DcuR -
H1C92_RS19815 4090611..4092242 - 1632 WP_001216461.1 sensor histidine kinase -
H1C92_RS19820 4092423..4092653 + 231 WP_000371698.1 (4Fe-4S)-binding protein -
H1C92_RS19825 4092665..4092937 + 273 WP_000405647.1 N-acetyltransferase -
H1C92_RS19830 4093164..4093460 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
H1C92_RS19835 4093488..4093661 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
H1C92_RS19840 4093780..4095297 - 1518 WP_001295074.1 lysine--tRNA ligase -
H1C92_RS19845 4095534..4096991 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T289105 WP_001173343.1 NZ_LR778141:4093488-4093661 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT289105 WP_000398619.1 NZ_LR778141:4093164-4093460 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References