Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3557291..3558126 Replicon chromosome
Accession NZ_LR778141
Organism Escherichia coli isolate SC407

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag H1C92_RS17390 Protein ID WP_085447097.1
Coordinates 3557749..3558126 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag H1C92_RS17385 Protein ID WP_115425271.1
Coordinates 3557291..3557659 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C92_RS17365 3555046..3555864 + 819 WP_115425206.1 DUF945 domain-containing protein -
H1C92_RS17370 3555956..3556441 + 486 WP_174490312.1 antirestriction protein -
H1C92_RS17375 3556457..3556933 + 477 WP_001186773.1 RadC family protein -
H1C92_RS17380 3556996..3557217 + 222 WP_000692323.1 DUF987 domain-containing protein -
H1C92_RS17385 3557291..3557659 + 369 WP_115425271.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
H1C92_RS17390 3557749..3558126 + 378 WP_085447097.1 type IV toxin-antitoxin system toxin CbtA Toxin
H1C92_RS17395 3558123..3558320 + 198 Protein_3401 hypothetical protein -
H1C92_RS17400 3558348..3558545 + 198 WP_089581460.1 DUF957 domain-containing protein -
H1C92_RS17405 3559463..3562507 + 3045 WP_089592676.1 autotransporter outer membrane beta-barrel domain-containing protein -
H1C92_RS17410 3562815..3562916 + 102 Protein_3404 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeJ / faeI / faeH / faeF / faeE / faeD / faeC 3521628..3562507 40879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14101.24 Da        Isoelectric Point: 8.5162

>T289103 WP_085447097.1 NZ_LR778141:3557749-3558126 [Escherichia coli]
MKTLPVLPGQAVSSRLSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEVKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13562.36 Da        Isoelectric Point: 5.5269

>AT289103 WP_115425271.1 NZ_LR778141:3557291-3557659 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References