Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2743235..2744070 Replicon chromosome
Accession NZ_LR778141
Organism Escherichia coli isolate SC407

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1L4J186
Locus tag H1C92_RS13445 Protein ID WP_000854742.1
Coordinates 2743693..2744070 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L4J164
Locus tag H1C92_RS13440 Protein ID WP_001406130.1
Coordinates 2743235..2743603 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C92_RS13410 2740065..2740520 + 456 WP_000581504.1 hypothetical protein -
H1C92_RS13415 2740599..2740832 + 234 WP_001119729.1 DUF905 family protein -
H1C92_RS13420 2740932..2741750 + 819 WP_001234648.1 DUF945 domain-containing protein -
H1C92_RS13425 2741805..2742290 + 486 WP_000849582.1 antirestriction protein -
H1C92_RS13430 2742306..2742782 + 477 WP_001186725.1 RadC family protein -
H1C92_RS13435 2742851..2743072 + 222 WP_000692345.1 DUF987 domain-containing protein -
H1C92_RS13440 2743235..2743603 + 369 WP_001406130.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H1C92_RS13445 2743693..2744070 + 378 WP_000854742.1 TA system toxin CbtA family protein Toxin
H1C92_RS13450 2744067..2744555 + 489 WP_000777551.1 hypothetical protein -
H1C92_RS13455 2744567..2744764 + 198 WP_000839267.1 DUF957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14236.28 Da        Isoelectric Point: 8.2976

>T289099 WP_000854742.1 NZ_LR778141:2743693-2744070 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTHSQLINSIDILRARRATGLMTRSNYRMVNDITRGKHSEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13717.53 Da        Isoelectric Point: 7.0269

>AT289099 WP_001406130.1 NZ_LR778141:2743235-2743603 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4J186

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4J164

References