Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2149074..2149699 Replicon chromosome
Accession NZ_LR778141
Organism Escherichia coli isolate SC407

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1C92_RS10670 Protein ID WP_000911330.1
Coordinates 2149074..2149472 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H1C92_RS10675 Protein ID WP_000450524.1
Coordinates 2149472..2149699 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C92_RS10650 2144952..2145152 + 201 WP_000383836.1 YpfN family protein -
H1C92_RS10655 2145262..2145960 - 699 WP_000679823.1 esterase -
H1C92_RS10660 2146034..2148049 - 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
H1C92_RS10665 2148064..2148927 - 864 WP_001267508.1 neutral zinc metallopeptidase -
H1C92_RS10670 2149074..2149472 - 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
H1C92_RS10675 2149472..2149699 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H1C92_RS10680 2149853..2150566 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H1C92_RS10685 2150779..2151813 - 1035 WP_001358397.1 outer membrane protein assembly factor BamC -
H1C92_RS10690 2151830..2152708 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H1C92_RS10695 2152854..2153426 + 573 WP_000176191.1 glycine cleavage system transcriptional repressor -
H1C92_RS10700 2153426..2153896 + 471 WP_001068677.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T289096 WP_000911330.1 NZ_LR778141:c2149472-2149074 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289096 WP_000450524.1 NZ_LR778141:c2149699-2149472 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References