Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1184321..1184847 Replicon chromosome
Accession NZ_LR778141
Organism Escherichia coli isolate SC407

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H1C92_RS05935 Protein ID WP_000323025.1
Coordinates 1184321..1184608 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H1C92_RS05940 Protein ID WP_000534858.1
Coordinates 1184608..1184847 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C92_RS05895 1179604..1179819 - 216 WP_000839590.1 phage lysis protein EssD -
H1C92_RS05900 1180573..1180788 - 216 WP_000066484.1 cold shock-like protein CspB -
H1C92_RS05905 1181087..1181289 + 203 Protein_1154 cold shock-like protein CspF -
H1C92_RS05910 1181464..1182216 - 753 WP_001047131.1 antitermination protein -
H1C92_RS05915 1182230..1183279 - 1050 WP_001265196.1 DUF968 domain-containing protein -
H1C92_RS05920 1183281..1183559 - 279 WP_023140913.1 hypothetical protein -
H1C92_RS05925 1183626..1183877 - 252 WP_000980999.1 hypothetical protein -
H1C92_RS05930 1184094..1184249 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
H1C92_RS05935 1184321..1184608 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H1C92_RS05940 1184608..1184847 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H1C92_RS05945 1184872..1185177 + 306 WP_001326990.1 hypothetical protein -
H1C92_RS05950 1185380..1185712 + 333 WP_001349760.1 FlxA-like family protein -
H1C92_RS05955 1186149..1187489 - 1341 WP_000589013.1 ISNCY family transposase -
H1C92_RS05960 1188258..1188544 - 287 Protein_1165 hypothetical protein -
H1C92_RS24660 1188710..1188892 - 183 Protein_1166 hypothetical protein -
H1C92_RS05965 1189155..1189511 - 357 WP_001315552.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1148861..1199194 50333


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289090 WP_000323025.1 NZ_LR778141:c1184608-1184321 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289090 WP_000534858.1 NZ_LR778141:c1184847-1184608 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References