Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1008531..1009169 Replicon chromosome
Accession NZ_LR778141
Organism Escherichia coli isolate SC407

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H1C92_RS05095 Protein ID WP_000813794.1
Coordinates 1008531..1008707 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H1C92_RS05100 Protein ID WP_001270285.1
Coordinates 1008753..1009169 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C92_RS05075 1004150..1005364 - 1215 WP_001326689.1 BenE family transporter YdcO -
H1C92_RS05080 1005417..1005953 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
H1C92_RS05085 1006026..1007987 + 1962 Protein_991 23S rRNA 5-hydroxycytidine C2501 synthase -
H1C92_RS05090 1008079..1008309 - 231 WP_000494244.1 YncJ family protein -
H1C92_RS05095 1008531..1008707 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H1C92_RS05100 1008753..1009169 + 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H1C92_RS05105 1009248..1010654 + 1407 WP_000760594.1 PLP-dependent aminotransferase family protein -
H1C92_RS05110 1010899..1012044 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
H1C92_RS05115 1012062..1013075 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
H1C92_RS05120 1013076..1014017 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1002962..1004110 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T289089 WP_000813794.1 NZ_LR778141:1008531-1008707 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT289089 WP_001270285.1 NZ_LR778141:1008753-1009169 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References