Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2588358..2588996 Replicon chromosome
Accession NZ_LR778140
Organism Escherichia coli isolate SC406

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H1C94_RS12340 Protein ID WP_000813794.1
Coordinates 2588820..2588996 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H1C94_RS12335 Protein ID WP_001270285.1
Coordinates 2588358..2588774 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C94_RS12315 2583510..2584451 - 942 WP_001251315.1 ABC transporter permease -
H1C94_RS12320 2584452..2585465 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
H1C94_RS12325 2585483..2586628 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
H1C94_RS12330 2586873..2588279 - 1407 WP_000760594.1 PLP-dependent aminotransferase family protein -
H1C94_RS12335 2588358..2588774 - 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H1C94_RS12340 2588820..2588996 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H1C94_RS12345 2589218..2589448 + 231 WP_000494244.1 YncJ family protein -
H1C94_RS12350 2589540..2591501 - 1962 Protein_2415 23S rRNA 5-hydroxycytidine C2501 synthase -
H1C94_RS12355 2591574..2592110 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
H1C94_RS12360 2592163..2593377 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2593417..2594565 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T289074 WP_000813794.1 NZ_LR778140:c2588996-2588820 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT289074 WP_001270285.1 NZ_LR778140:c2588774-2588358 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References