Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2412680..2413206 Replicon chromosome
Accession NZ_LR778140
Organism Escherichia coli isolate SC406

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H1C94_RS11500 Protein ID WP_000323025.1
Coordinates 2412919..2413206 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H1C94_RS11495 Protein ID WP_000534858.1
Coordinates 2412680..2412919 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C94_RS11470 2408015..2408372 + 358 Protein_2239 class I SAM-dependent methyltransferase -
H1C94_RS23755 2408635..2408817 + 183 Protein_2240 hypothetical protein -
H1C94_RS11475 2408983..2409269 + 287 Protein_2241 hypothetical protein -
H1C94_RS11480 2410038..2411378 + 1341 WP_000589013.1 ISNCY family transposase -
H1C94_RS11485 2411815..2412147 - 333 WP_001349760.1 FlxA-like family protein -
H1C94_RS11490 2412350..2412655 - 306 WP_001326990.1 hypothetical protein -
H1C94_RS11495 2412680..2412919 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H1C94_RS11500 2412919..2413206 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H1C94_RS11505 2413278..2413433 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
H1C94_RS11510 2413650..2413901 + 252 WP_000980999.1 hypothetical protein -
H1C94_RS11515 2413968..2414246 + 279 WP_023140913.1 hypothetical protein -
H1C94_RS11520 2414248..2415297 + 1050 WP_001265196.1 DUF968 domain-containing protein -
H1C94_RS11525 2415311..2416063 + 753 WP_001047131.1 antitermination protein -
H1C94_RS11530 2416238..2416440 - 203 Protein_2252 cold shock-like protein CspF -
H1C94_RS11535 2416739..2416954 + 216 WP_000066484.1 cold shock-like protein CspB -
H1C94_RS11540 2417708..2417923 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2387784..2448667 60883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289073 WP_000323025.1 NZ_LR778140:2412919-2413206 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289073 WP_000534858.1 NZ_LR778140:2412680-2412919 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References