Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1054092..1054746 Replicon chromosome
Accession NZ_LR778140
Organism Escherichia coli isolate SC406

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag H1C94_RS05010 Protein ID WP_000244772.1
Coordinates 1054339..1054746 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag H1C94_RS05005 Protein ID WP_000354046.1
Coordinates 1054092..1054358 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C94_RS04980 1049380..1050123 + 744 WP_000951965.1 SDR family oxidoreductase -
H1C94_RS04985 1050180..1051613 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
H1C94_RS04990 1051658..1051969 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
H1C94_RS04995 1052133..1052792 + 660 WP_000250274.1 hemolysin III family protein -
H1C94_RS05000 1052869..1053849 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
H1C94_RS05005 1054092..1054358 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
H1C94_RS05010 1054339..1054746 + 408 WP_000244772.1 protein YgfX Toxin
H1C94_RS05015 1054786..1055307 - 522 WP_001055874.1 flavodoxin FldB -
H1C94_RS05020 1055419..1056315 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H1C94_RS05025 1056340..1057050 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H1C94_RS05030 1057056..1058789 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T289065 WP_000244772.1 NZ_LR778140:1054339-1054746 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT289065 WP_000354046.1 NZ_LR778140:1054092-1054358 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References