Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 714631..715661 Replicon chromosome
Accession NZ_LR777867
Organism Corynebacterium diphtheriae isolate NCTC11397

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NCTC11397BIS_RS03555 Protein ID WP_070794874.1
Coordinates 714631..715050 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A806GUF5
Locus tag NCTC11397BIS_RS03560 Protein ID WP_014318824.1
Coordinates 715095..715661 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC11397BIS_RS03540 (LRS77_RS03515) 711288..712142 + 855 WP_014303121.1 hypothetical protein -
NCTC11397BIS_RS03545 (LRS77_RS03520) 712135..713043 - 909 WP_014309246.1 DUF1906 domain-containing protein -
NCTC11397BIS_RS03550 (LRS77_RS03525) 713172..714371 - 1200 WP_014318823.1 cation:proton antiporter -
NCTC11397BIS_RS03555 (LRS77_RS03530) 714631..715050 - 420 WP_070794874.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NCTC11397BIS_RS03560 (LRS77_RS03535) 715095..715661 - 567 WP_014318824.1 Panacea domain-containing protein Antitoxin
NCTC11397BIS_RS03565 (LRS77_RS03540) 715994..716269 + 276 WP_014309249.1 hypothetical protein -
NCTC11397BIS_RS03575 (LRS77_RS03550) 716941..717216 + 276 WP_014301596.1 hypothetical protein -
NCTC11397BIS_RS03580 (LRS77_RS03555) 717223..717975 + 753 WP_014318826.1 precorrin-6A synthase (deacetylating) -
NCTC11397BIS_RS03585 (LRS77_RS03560) 717994..718251 - 258 WP_010934589.1 mycoredoxin -
NCTC11397BIS_RS03590 (LRS77_RS03565) 718272..718775 - 504 WP_014303129.1 dihydrofolate reductase -
NCTC11397BIS_RS03595 (LRS77_RS03570) 718775..719587 - 813 WP_014318827.1 thymidylate synthase -
NCTC11397BIS_RS03600 (LRS77_RS03575) 719681..720439 - 759 WP_014318828.1 3'(2'),5'-bisphosphate nucleotidase CysQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 714631..725292 10661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(11-93)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15477.61 Da        Isoelectric Point: 8.2756

>T289060 WP_070794874.1 NZ_LR777867:c715050-714631 [Corynebacterium diphtheriae]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 420 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21053.55 Da        Isoelectric Point: 4.5592

>AT289060 WP_014318824.1 NZ_LR777867:c715661-715095 [Corynebacterium diphtheriae]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806GUF5

References