Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2802254..2802963 Replicon chromosome
Accession NC_020245
Organism Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag K60_RS13110 Protein ID WP_003413164.1
Coordinates 2802254..2802667 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag K60_RS13115 Protein ID WP_003413167.1
Coordinates 2802706..2802963 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K60_RS13080 2797964..2798278 + 315 WP_009937839.1 hypothetical protein -
K60_RS13085 2798574..2799785 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
K60_RS13090 2799912..2800571 + 660 WP_003900846.1 LppA family lipoprotein -
K60_RS13095 2800568..2801227 + 660 WP_003900847.1 hypothetical protein -
K60_RS13100 2801224..2801886 + 663 WP_003900848.1 hypothetical protein -
K60_RS13105 2801883..2802161 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
K60_RS13110 2802254..2802667 + 414 WP_003413164.1 PIN domain nuclease Toxin
K60_RS13115 2802706..2802963 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
K60_RS13120 2802960..2803337 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
K60_RS13125 2803353..2803727 - 375 WP_003413177.1 hypothetical protein -
K60_RS13130 2803827..2804222 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
K60_RS13135 2804219..2804464 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
K60_RS13140 2804875..2805294 - 420 WP_003413190.1 A24 family peptidase -
K60_RS13145 2805306..2806133 - 828 WP_010950736.1 shikimate dehydrogenase -
K60_RS13150 2806111..2807364 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
K60_RS13155 2807357..2807869 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T28906 WP_003413164.1 NC_020245:2802254-2802667 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T28906 NC_020245:2802254-2802667 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT28906 WP_003413167.1 NC_020245:2802706-2802963 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT28906 NC_020245:2802706-2802963 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References